abstract：:Atypical antipsychotics, including olanzapine, were originally expected to reduce the risk of haematological toxicity and to be safe alternatives to clozapine. We report a case of patient who developed leucopenia and neutropenia during treatment with olanzapine. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Stergiou V,Bozikas VP,Garyfallos G,Nikolaidis N,Lavrentiadis G,Fokas K

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Chronic substance abuse has been associated with decrements in the processing and expression of language. The present study utilized the N400 event-related electroencephalographic potential to index semantic processing in 133 adults with (n=49) or without (n=84) a history of alcohol and/or cocaine dependence...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ceballos NA,Houston RJ,Smith ND,Bauer LO,Taylor RE

更新日期：2005-07-01 00:00:00

abstract：:This study was performed to investigate the anxiolytic-like effects of red ginseng (RG, steamed raw ginseng at 98-100 degrees C) and sun ginseng (SG, heat-processed ginseng at higher temperature) in mice using the elevated plus-maze model. Furthermore, the anxiolytic-like effects of RG and SG were compared to a known ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Park JH,Cha HY,Seo JJ,Hong JT,Han K,Oh KW

更新日期：2005-07-01 00:00:00

abstract：:Studies of twins, genetic linkage and association support the existence of a genetic component to the susceptibility to depression. Biochemical parameters that change in depressive patients are also observed in their relatives. This indicates that genetic factors control these physiological changes and the susceptibil...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Páez-Pereda M

更新日期：2005-07-01 00:00:00

abstract：:The role of GABAergic mechanism in the convulsant effect of mefloquine was investigated in mice. Mefloquine dose dependently induced tonic seizures in mice. Aminooxyacetic acid, diaminobutyric acid and muscimol significantly protected mice against mefloquine-induced seizures by significantly delaying the onset and dec...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Amabeoku GJ,Farmer CC

更新日期：2005-07-01 00:00:00

abstract：:This study evaluated the overall effectiveness and tolerability of adjunctive quetiapine as a continuation therapy for the long-term treatment of bipolar mania. Twenty-three patients were enrolled in this study and received quetiapine add-on treatment in combination with their existing or new mood stabilizers. The cli...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pae CU,Kim TS,Kim JJ,Lee SJ,Lee CU,Lee C,Paik IH

更新日期：2005-06-01 00:00:00

abstract：:Little is known about biological predictors of treatment response in panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the putative common etiolog...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kobayashi K,Shimizu E,Hashimoto K,Mitsumori M,Koike K,Okamura N,Koizumi H,Ohgake S,Matsuzawa D,Zhang L,Nakazato M,Iyo M

更新日期：2005-06-01 00:00:00

abstract：:Major depression is a serious illness in children which adversely effects their social, academic, and emotional development. It is essential to identify safe and effective medication for the treatment of this disorder in youths. Only some selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline) hav...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wagner KD

更新日期：2005-06-01 00:00:00

abstract：:Many studies have shown a close relationship between anxiety and beta-adrenergic receptor function in patients with anxiety disorders. This study examined the relationship between beta-adrenergic receptor function and anxiety levels in a normal population. Subjects for this study included 36 men and 44 women between t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kang EH,Yu BH

更新日期：2005-06-01 00:00:00

abstract：:Several lines of evidence suggest that genetic factors might contribute to susceptibility to panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Shimizu E,Hashimoto K,Koizumi H,Kobayashi K,Itoh K,Mitsumori M,Ohgake S,Okamura N,Koike K,Matsuzawa D,Zhang L,Kumakiri C,Nakazato M,Komatsu N,Iyo M

更新日期：2005-06-01 00:00:00

abstract：:The effects of chronic ethanol consumption and ethanol withdrawal on serum cholinesterase (ChE) activity and passive avoidance task in rats were investigated. Ethanol was administered to rats by a modified liquid diet with 4.8% (v/v) ethanol for 3 days followed by 25 days on a liquid diet in which the ethanol concentr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Celik T,Cakir E,Kayir H,Bilgi C,Uzbay IT

更新日期：2005-05-01 00:00:00

abstract：:The phenomenon known as one-trial tolerance (OTT) to the anxiolytic effects of benzodiazepines observed in rats submitted to the elevated plus-maze test (EPM) is considered to be due to the emergence of phobic states across the test/retest sessions. Antinociception is a usual component of the defense reaction. Until n...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Albrechet-Souza L,Oliveira AR,De Luca MC,Tomazini FM,Santos NR,Brandão ML

更新日期：2005-05-01 00:00:00

abstract：:Memory decline in human aging and dementia is linked to dysfunction of the cholinergic system. Aging dogs demonstrate cognitive impairments and neuropathology that models human aging and dementia. This paper reviews recent evidence suggesting cholinergic involvement in canine cognitive aging based on studies with the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Araujo JA,Studzinski CM,Milgram NW

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The subjectively assessed quality of life of schizophrenia patients is mostly lower than healthy subjects, and cognitive impairment is an integral feature of schizophrenia. The aims of the present study were to compare the quality of life and neurocognitive functioning between the patients with schizophrenia...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Alptekin K,Akvardar Y,Kivircik Akdede BB,Dumlu K,Işik D,Pirinçci F,Yahssin S,Kitiş A

更新日期：2005-02-01 00:00:00

abstract：:The neuropeptide substance P (SP) has been suggested to be involved in several physiological and pathological conditions including learning and memory and the processing of pain. This study investigated for the first time acute effects of SP and the neurokinin-1 (NK-1) receptor antagonist L-733060 on long term potenti...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Langosch JM,Kupferschmid S,Heinen M,Walden J,Herpfer I,Fiebich BL,Lieb K

更新日期：2005-02-01 00:00:00

abstract：:The authors sought to determine whether sustained-release (SR) isradipine provided comparable systemic availability to that of immediate-release (IR) isradipine in non-treatment-seeking, cocaine-dependent individuals. This information could be used to design a rational dosage regimen for additional isradipine clinical...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Johnson BA,Javors MA,Lam YW,Wells LT,Tiouririne M,Roache JD,Ait-Daoud N,Lawson K

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare striatal dopaminergic D2 receptor occupancy (D2 RO) induced by ziprasidone and haloperidol and its relationship with clinical response and extrapyramidal side effects (EPS) in patients with acute psychosis exacerbation. METHOD:Twenty patients hospitalized with an acute ps...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Corripio I,Catafau AM,Perez V,Puigdemont D,Mena E,Aguilar Y,Carrió I,Alvarez E

更新日期：2005-01-01 00:00:00

abstract：:The authors present a case of obsessive-compulsive disorder (OCD) resistant to conventional treatments, which improved following nicotine augmentation administered as 4 mg chewing gum. The role of acetylcholine in the pathophysiology of OCD is not clear. The authors discuss the effect of nicotine on memory for actions...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pasquini M,Garavini A,Biondi M

更新日期：2005-01-01 00:00:00

abstract：:Previous studies have demonstrated dopaminergic (DA) modulation of stimulus selection performance in the overshadowing and Kamin blocking (KB) tasks. Systemic administration of the DA agonist D-amphetamine selectively disrupted overshadowing in the rat. In the present study, we examined the ability of the selective DA...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： O'Tuathaigh CP,Moran PM

更新日期：2004-12-01 00:00:00

abstract：:Altered stress responsiveness has been repeatedly related to mood and anxiety disorders. In a traditional view, a reduction of the stress response has been thought favorable. The goal of the present study was to verify the hypothesis that high anxiety is accompanied by enhanced hormone release during stress. Healthy s...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Jezova D,Makatsori A,Duncko R,Moncek F,Jakubek M

更新日期：2004-12-01 00:00:00

abstract：:The present study sought to assess whether the blockade of ionotropic glutamate receptors in the ventral tegmental area (VTA) could modulate the morphine withdrawal in male Sprague-Dawley rats. The effects of dizocilpine (MK-801) or 6,7-dinitroquinnoxaline-2,3-dione (DNQX), ionotropic glutamate receptor antagonists, m...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang HL,Zhao Y,Xiang XH,Wang HS,Wu WR

更新日期：2004-11-01 00:00:00

abstract：:The aim of the work was to study the effects of litter and the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) on the behaviour of mice after acute and chronic ethanol administration and withdrawal. Male outbred NIH/S mice, from 21 litters, were distributed among experimental groups and subjected t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Okva K,Lang A,Pokk P,Väli M,Nevalainen T

更新日期：2004-11-01 00:00:00

abstract：:Despite a growing body of evidence demonstrating that mitogen-activated protein (MAP) kinase pathways play an important physiological role in the CNS, little is known about their role and function in various mental disorders including schizophrenia. Our previous studies have shown increased expression of several inter...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kyosseva SV

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To explore the status of the psychotropic medication in persons with mental retardation 6 years after their deinstitutionalization. METHOD:The authors compared the profiles of psychotropic medication of 60 persons with mental retardation deinstitutionalized (D-sample) from our local mental hospital 6 years a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Radouco-Thomas M,Bolduc M,Brisson A,Brassard P,Fortier L,Thivierge J

更新日期：2004-08-01 00:00:00

abstract：:Neuropathological abnormalities in schizophrenia have been demonstrated in the parahippocampal gyrus (PHG). Only a few studies on first-episode neuroleptic-naive schizophrenia patients have been done using in vivo neuroimaging techniques. The authors examined the PHG morphology using structural MRI in neuroleptic-naiv...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Prasad KM,Rohm BR,Keshavan MS

更新日期：2004-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the putative antidepressive and cognitive enhancer effects of phosphatidylserine (BC-PS). The antidepressive effect of BC-PS (50, 100 or 200 mg/kg), compared to saline or imipramine (IMI; 25 mg/kg), was studied in the forced swimming test in rats. These drugs were administe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Castilho JC,Perry JC,Andreatini R,Vital MA

更新日期：2004-07-01 00:00:00

abstract：:The role of the monoamines serotonin and noradrenaline in mental illnesses including depression is well recognized. All antidepressant drugs in clinical use increase acutely the availability of these monoamines at the synapse either by inhibiting their neuronal reuptake, inhibiting their intraneuronal metabolism, or i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Elhwuegi AS

更新日期：2004-05-01 00:00:00

abstract：:Inhibition of inositol monophosphatase (IMPase) enzyme is the target mechanism of action of lithium. However, increased activity of mRNA levels by lithium has been reported. These two diverse effects were shown after relatively short periods of lithium administration. The aim of this study was to observe the effect of...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kaya N,Resmi H,Ozerdem A,Guner G,Tunca Z

更新日期：2004-05-01 00:00:00

abstract：:A 33-year-old male suffering from schizophrenia developed the typical symptoms of Cotard's syndrome, i.e., various delusions of negation and severe depressive symptoms. Atypical symptoms such as delusions of persecution and control related to body parts were also observed. These symptoms gradually improved by the trea...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Shiraishi H,Ito M,Hayashi H,Otani K

更新日期：2004-05-01 00:00:00

abstract：:The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ozer S,Uluşahin A,Ulusoy S,Okur H,Coşkun T,Tuncali T,Göğüş A,Akarsu AN

更新日期：2004-03-01 00:00:00

abstract：:A battery of neuropsychological measures considered sensitive to dysfunction in prefrontal or temporal cortices was administered to patients with borderline personality disorder (BPD) and healthy controls. BPD patients exhibited striking deficits on measures of nonverbal executive function and nonverbal memory but wer...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dinn WM,Harris CL,Aycicegi A,Greene PB,Kirkley SM,Reilly C

更新日期：2004-03-01 00:00:00

abstract：:Estimates of the reported prevalence of visual hallucinations in the elderly vary from study to study. The aim of the present investigation was to re-evaluate the prevalence of visual hallucinations in elderly psychiatric outpatients and to examine pertinent risk factors. One hundred and twenty-two elderly (> or =60 y...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Soeda S,Terao T,Nishimura M,Nakamura J,Iwata N

更新日期：2004-03-01 00:00:00

abstract：:The purpose of the present study was to investigate cumulative heroin effects on brain functioning by studying relationships among electroencephalography (EEG) spectral power and mean frequencies and heroin abuse history. Eyes-closed resting EEG data were collected from the 19 monopolar electrode sites in 33 heroin ab...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Polunina AG,Davydov DM

更新日期：2004-01-01 00:00:00

abstract：:There is an increasing awareness that a psychosis, similar to that of schizophrenic psychosis, can be derived from cocaine addiction. Thus, the prototypical atypical antipsychotic medication, clozapine, a 5-HT(2)/DA(2) antagonist, was studied for its effects on cocaine-induced dopamine (DA) and serotonin (5-HT) releas...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Broderick PA,Hope O,Okonji C,Rahni DN,Zhou Y

更新日期：2004-01-01 00:00:00

abstract：:Amisulpride clearly has the clinical profile of an atypical antipsychotic, characterised in particular by its lower propensity to induce extrapyramidal side effects as well as its greater efficacy in treating negative symptoms compared with classical neuroleptics. In addition to the clinical advantages over classical ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Möller HJ

更新日期：2003-10-01 00:00:00

abstract：:Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus as unconditioned stimulus (US). Much evidence has also been provided for the involvement of dopamine in the setting up of adaptive responses to aversive states generated at this mesencephali...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Masson S,Avanzi V,Troncoso AC,Brandão ML

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:To evaluate the safety and potential beneficial effect of topiramate (TPM) as monotherapy or adjunctive therapy to carbamazepine (CBZ) in patients with cerebellar tremor. METHODS:Nine patients with cerebellar tremor participated a 4-week, open-label, prospective-controlled trial. TPM was given as monotherapy (...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sechi G,Agnetti V,Sulas FM,Sau G,Corda D,Pitzolu MG,Rosati G

更新日期：2003-09-01 00:00:00

abstract：:Ibogaine (IBO) is an alkaloid with putative antiaddictive properties, alleviating opiates dependence and withdrawal. The glutamate N-methyl-D-aspartate (NMDA) receptors have been implicated in the physiological basis of drug addiction; accordingly, IBO acts as a noncompetitive NMDA antagonist. The purpose of this stud...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Leal MB,Michelin K,Souza DO,Elisabetsky E

更新日期：2003-08-01 00:00:00

abstract：:Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sokolski KN,Denson TF

更新日期：2003-08-01 00:00:00

abstract：:Degeneration of cholinergic cortical neurons is one of the main reasons for the cognitive deficit in dementia of the Alzheimer type (AD) and in dementia with Lewy bodies (DLB). Many subjects with AD and DLB have extrapyramidal dysfunction and depression resulting from degeneration of dopaminergic, noradrenergic and se...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Weinstock M,Gorodetsky E,Poltyrev T,Gross A,Sagi Y,Youdim M

更新日期：2003-06-01 00:00:00